Evaluating proxies for motion sickness in rodent

Motions sickness (MS) occurs when the brain receives conflicting sensory signals from vestibular, visual and proprioceptive systems about a person’s ongoing position and/or motion in relation to space. MS is typified by symptoms such as nausea emesis implicates complex physiological aspects of sensations sensorimotor reflexes. Use animal models has been integral unraveling causality MS. The commonly used rodents (rat mouse), albeit lacking vomiting reflex, reliably display phenotypic behaviors pica (eating non-nutritive substance) conditioned taste aversion (CTAver) or avoidance (CTAvoi) which utilize neural substrates with pathways that cause gastrointestinal malaise akin nausea/emesis. As such, rodent CTAver/CTAvoi have widely proxies for nausea/emesis studies dealing mechanisms MS, well evaluating therapeutics. This review presents rationale experimental evidence support use indices emesis. Key steps cautions required using are also discussed. Finally, future directions suggested studying models.